Iselin disease

What Causes Iselin Disease?

Last updated on February 14th, 2024 at 02:15 pm

Iselin disease, also known as apophysitis of the 5th metatarsal, is a relatively rare but painful foot condition. It affects the growth plate near the base of the fifth metatarsal bone in the foot. This condition typically occurs in children and adolescents during their growth spurts. Often causing inflammation and pain on the foot’s outer side. Iselin Disease in adults is very rare, but not unheard of.  

Understanding what causes the condition is essential for parents, coaches, and healthcare providers. It allows them to identify early warning signs and take preventive measures. Some of the primary factors causing this condition include trauma or injury to the foot, repetitive stress, and genetic predisposition. This article will delve deeper into these causes and their impact on the growth plate. Further, emphasising the importance of early diagnosis and treatment.

Anatomy and Physiology Iselin Disease

The growth plate, or the epiphyseal plate or physis, is a cartilaginous region found at the ends of long bones in children and adolescents. It plays a crucial role in the growth and development of the bones. As children grow, the growth plate gradually transforms into solid bone through a process called ossification. This process continues until the individual reaches skeletal maturity. At this point, the growth plate is entirely replaced by bone, and no further growth occurs.

Role of the 5th metatarsal in the foot

The 5th metatarsal is one of the five long bones in the foot. It is situated on the foot’s outer side, connecting the midfoot to the toe. It plays a vital role in maintaining balance, weight distribution, and supporting the lateral (outer) edge of the foot during various activities such as walking, running, and jumping. The Iselin disease specifically affects the growth plate at the base of the 5th metatarsal, known as the apophysis. This growth plate is essential for the normal development and lengthening of the 5th metatarsal bone. Any disruption to its function may result in pain and other complications.

Causes of Iselin Disease

Trauma or injury to the foot

Iselin disease occurs due to various types of trauma or injury to the foot. These injuries may include direct impacts, such as a collision or a fall, or indirect forces, such as a sudden twist or overextension of the foot. In some cases, even minor injuries can lead to developing Iselin disease, particularly in children and adolescents with pre-existing risk factors.

When trauma occurs, it can cause damage to the growth plate at the base of the 5th metatarsal, leading to inflammation and pain. This damage disrupts the normal growth and development process. This causes the growth plate to become inflamed and irritated, which results in the symptoms associated with Iselin disease.

Repetitive stress

Repetitive stress on the foot is another common cause of Iselin disease. High-impact sports and activities that involve frequent running, jumping, or pivoting, such as soccer, basketball, gymnastics, and dance, can put excessive strain on the growth plate of the 5th metatarsal. This repetitive stress increases the risk of developing Iselin disease, particularly in young athletes experiencing rapid growth.

The strain caused by repetitive stress can lead to microtrauma, tiny injuries to the growth plate that may not be noticeable initially but can accumulate over time. This microtrauma can weaken the growth plate, making it more susceptible to inflammation and causing the pain and swelling characteristic of Iselin disease.

Genetics 

Although the exact role of genetics in the development of Iselin disease is not fully understood, some studies suggest that certain individuals may be genetically predisposed to the condition. These genetic factors could influence the structure and function of the growth plate, making it more susceptible to injury or inflammation.

Inherited foot structures, such as flat feet or high arches, can also contribute to the development of Iselin disease. These structural abnormalities may alter the distribution of weight and stress on the foot, placing additional strain on the growth plate at the base of the 5th metatarsal. As a result, individuals with these inherited foot structures may be at a higher risk of developing the condition.

Risk Factors for Iselin Disease

Age and gender

Iselin disease primarily affects children and adolescents, typically between the ages of 8 and 15, as this is the period when they experience significant growth spurts. During these growth spurts, the growth plate is more active and thus more vulnerable to injury and inflammation. Although any young person can develop Iselin disease, some studies suggest that it may be slightly more common in boys due to differences in growth patterns and physical activity levels.

Participation in high-impact sports

As mentioned, participation in high-impact sports and activities involving frequent running, jumping, or pivoting increases the risk of developing Iselin disease. Young athletes who engage in sports such as soccer, basketball, gymnastics, and dance may experience repetitive stress on the growth plate, leading to the development of the condition. Parents, coaches, and healthcare providers must become aware of this risk and monitor young athletes for early signs of Iselin disease.

Pre-existing foot conditions

Individuals with pre-existing foot conditions, such as flat feet, high arches, or other structural abnormalities, may be at a higher risk of developing Iselin disease. These conditions can alter the distribution of weight and stress on the foot, placing additional strain on the growth plate at the base of the 5th metatarsal. It is essential for parents and healthcare providers to be aware of these risk factors and to take appropriate measures, such as providing supportive footwear or orthotic devices, to minimise the risk of Iselin disease in children and adolescents with pre-existing foot conditions.

Diagnosing and Treating Iselin Disease

Importance of early diagnosis

Early diagnosis of Iselin disease is crucial to ensure appropriate treatment and prevent complications. If left untreated, the condition can result in chronic pain, reduced mobility, and, in severe cases, permanent damage to the growth plate. Identifying Iselin disease in its early stages allows for prompt intervention and a better chance of full recovery.

Diagnostic methods

The diagnosis of Iselin disease typically begins with a thorough physical examination by a healthcare professional. The examination will involve assessing the patient’s foot for signs of inflammation, swelling, and tenderness near the base of the 5th metatarsal. The healthcare provider may also evaluate the patient’s gait, range of motion, and overall foot function to determine the severity of the condition.

In some cases, imaging techniques such as X-rays, ultrasound, or magnetic resonance imaging (MRI) may be used to confirm the diagnosis and assess the extent of the damage to the growth plate. These imaging studies can help rule out other conditions, such as fractures or infections, that may cause similar symptoms.

Treatment options

The primary treatment for Iselin disease is conservative management, which aims to reduce inflammation and pain while promoting healing of the growth plate. This approach typically involves a combination of rest, ice, compression, and elevation (RICE), along with over-the-counter pain relievers and anti-inflammatory medications as needed. In some cases, a walking boot or cast may be necessary to immobilise the affected foot and allow the growth plate to heal. Physical therapy and rehabilitation are the recommended exercises to restore strength, flexibility, and function to the foot.

Surgical intervention is rarely required for Iselin disease. It is typically reserved for severe cases that do not respond to conservative management or in situations where the growth plate has been significantly damaged. Surgery may involve the removal of excess bone or cartilage, stabilising the growth plate, or other procedures to address the condition’s underlying cause. The specific surgical approach will depend on the patient’s needs and the damage to the growth plate.

Conclusion

Iselin disease is a condition that affects the growth plate of the 5th metatarsal bone in the foot. Typically, trauma or injury to the foot, repetitive stress from high-impact sports or activities, and genetic factors such as inherited foot structure are contributing factors. Early diagnosis and treatment are essential in managing Iselin disease effectively and preventing complications.

It is crucial to recognise the symptoms of Iselin disease, such as pain, swelling, and tenderness near the base of the 5th metatarsal, and seek medical help promptly if experiencing these symptoms. A thorough physical examination and imaging studies can confirm the diagnosis and rule out other lateral foot pain. Conservative management, including rest, ice, compression, elevation, and medication, is typically the first line of treatment. In some cases, surgical intervention is necessary for severe cases or when the growth plate has been significantly damaged.

If you suspect your child or someone you know may have Iselin disease, it is essential to consult a doctor for proper evaluation and management. Early diagnosis and treatment can lead to better outcomes and a quicker recovery. Remember, your health is your wealth!

FAQs 

1. Can Iselin disease affect both feet? 

Yes, Iselin disease can affect both feet, although it typically occurs on one foot. 

2. Is Iselin disease a common condition? 

It is relatively rare compared to other foot conditions. It commonly affects adolescents and young athletes who participate in high-impact sports.

3. Is the disease preventable? 

The disease is not always preventable, there are steps to help reduce the risk of developing the disease. This includes avoiding trauma or repetitive stress to the foot, wearing appropriate footwear, using proper techniques and equipment in sports or activities, and maintaining good foot health through regular exercise and stretching.

4. How long does it take to recover from Iselin disease? 

The recovery time varies depending on the severity of the condition and the treatment approach. With conservative management, including rest, ice, compression, elevation, and medication, most cases of Iselin disease resolve within a few weeks to a few months. Longer recovery time for severe cases or surgical intervention.

5. Can Iselin disease recur after treatment? 

Yes, it can recur after treatment, especially if the underlying causes, such as trauma or repetitive stress, are not addressed. It is essential to follow the recommended treatment plan, including any lifestyle modifications or rehabilitation exercises, and to continue practising good foot health habits to reduce the risk of recurrence.

Rohan Newman MSc MRCPod

Rohan Newman is a qualified podiatrist and teacher with many years of experience and extensive training, with a diploma in education, a BA in physical education, a BSc (Hons) 1st Class in podiatry and an MSc in sports health.

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